Clinical Neurology

With the capabilities of constant monitoring of oxygenation, perfusion and autoregulation, fNIRS has a high potential for diagnoses of cerebrovascular disease and severe brain injury. Other clinical neurology methodologies, including epileptic disorders and central nervous system tumors, may benefit from the technique on the preoperative function localization.

Gilman, J. M., Yücel, M. A., Pachas, G. N., Potter, K., Levar, N., Broos, H., ... & Evins, A. E. (2019). “Delta-9-tetrahydrocannabinol intoxication is associated with increased prefrontal activation as assessed with functional near-infrared spectroscopy: A report of a potential biomarker of intoxication”. NeuroImage, 197, 575-585.

Sagiv, S. K., Bruno, J. L., Baker, J. M., Palzes, V., Kogut, K., Rauch, S., ... & Eskenazi, B. (2019). “Prenatal exposure to organophosphate pesticides and functional neuroimaging in adolescents living in proximity to pesticide application.” Proceedings of the National Academy of Sciences, 116(37), 18347-18356.

Grazioli, S., Crippa, A., Mauri, M., Piazza, C., Bacchetta, A., Salandi, A., ... & Nobile, M. (2019). “Association between fatty acids profile and cerebral blood flow: An exploratory fNIRS study on children with and without ADHD”. Nutrients, 11(10), 2414.

R. Li, T. Nguyen, T. Potter, and Y. Zhang, “Dynamic cortical connectivity alterations associated with Alzheimer’s disease: An EEG and fNIRS integration study,” NeuroImage: Clinical, Dec. 2018.

F. Colledge, S. Ludyga, M. Mücke, U. Pühse, and M. Gerber, “The effects of an acute bout of exercise on neural activity in alcohol and cocaine craving: study protocol for a randomised controlled trial,” Trials, vol. 19, no. 1, p. 713, Dec. 2018.

O. Klempíř et al., “P 024 - Near-infrared spectroscopy patterns of cortical activity during gait in Parkinson’s disease patients treated with DBS STN,” Gait & Posture, vol. 65, pp. 273–275, Sep. 2018.

J. Eun-Sun et al., “Effect of acupuncture on patients with mild cognitive impairment assessed using functional near-infrared spectroscopy on week 12 (close-out): a pilot study protocol,” Integrative Medicine Research, vol. 7, no. 3, pp. 287–295, Sep. 2018.

A. Lee et al., “Slow oscillations of cerebral hemodynamics changes during low-level light therapy in the elderly with and without mild cognitive impairment: An fNIRS study,” Annals of Physical and Rehabilitation Medicine, vol. 61, p. e256, Jul. 2018.

J.-H. Jang, J. Lee, I. Jung, and H. Yoo, “Efficacy of Yokukansankachimpihange on sleep disturbance in Parkinson’s disease,” Medicine (Baltimore), vol. 97, no. 26, Jun. 2018.

C.-T. Li, C.-F. Lu, Y.-T. Wu, S.-H. Lee, R.-W. Chu, and T.-P. Su, “Attenuated Motor Cortical Responsiveness to Motor and Cognitive Tasks in Generalized Anxiety Disorder,” vol. 8, no. 3, pp. 843–853, May 2018.

C. S. H. Ho, R. C. M. Ho, and A. M. L. Quek, “Chronic Manganese Toxicity Associated with Voltage-Gated Potassium Channel Complex Antibodies in a Relapsing Neuropsychiatric Disorder,” International Journal of Environmental Research and Public Health, vol. 15, no. 4, p. 783, Apr. 2018.

O. Klempíř, R. Krupička, and R. Jech, “MEDIAN METHOD FOR DETERMINING CORTICAL BRAIN ACTIVITY IN A NEAR INFRARED SPECTROSCOPY IMAGE,” Lékař a technika - Clinician and Technology, vol. 48, no. 1, pp. 11–16, Mar. 2018.

M. Balconi, C. Siri, N. Meucci, G. Pezzoli, and L. Angioletti, “Personality Traits and Cortical Activity Affect Gambling Behavior in Parkinson’s Disease,” Journal of Parkinson’s Disease, vol. 8, no. 2, pp. 341–352, Jan. 2018.

R. Li, G. Rui, W. Chen, S. Li, P. E. Schulz, and Y. Zhang, “Early Detection of Alzheimer’s Disease Using Non-invasive Near-Infrared Spectroscopy,” Front. Aging Neurosci., vol. 10, 2018.

Z. Liang et al., “Design of multichannel functional near-infrared spectroscopy system with application to propofol and sevoflurane anesthesia monitoring,” NPh, NEUROW, vol. 3, no. 4, p. 045001, Oct. 2016.

A. M. Kempny et al., “Functional near infrared spectroscopy as a probe of brain function in people with prolonged disorders of consciousness,” NeuroImage: Clinical, vol. 12, pp. 312–319, Feb. 2016.

S. E. Kober, G. Bauernfeind, C. Woller, M. Sampl, P. Grieshofer, C. Neuper, and G. Wood, “Hemodynamic Signal Changes Accompanying Execution and Imagery of Swallowing in Patients with Dysphagia: A Multiple Single-Case Near-Infrared Spectroscopy Study,” Front Neurol, vol. 6, Jul. 2015.

H. Obrig, “NIRS in clinical neurology - a ‘promising’ tool?,” Neuroimage, vol. 85 Pt 1, pp. 535–546, Jan. 2014.

For the latest listing of clinical trials involving brain disorders, please visit:

http://www.ninds.nih.gov/disorders/clinical_trials/index.htm

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